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1. The effect of RunningMax application on vascular function in forearm skin microcirculation in young healthy individuals- Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Aim: The aim of this study was to test the effect of commercial product KP-0013-20 topical application on vascular function in forearm skin microcirculation in young healthy individuals.
Materials and Methods: 10 young healthy individuals of both sexes participated in this study (5 women and 5 men, age range 21-33). Upper arm skin microvascular blood flow was measured using a noninvasive laser Doppler flowmetry (LDF) before and after KP-0013-20 external (skin surface) application. As a control measurement, in the same subjects, regular ultrasound gel (placebo) was applicated on other hand and LDF measurement was done using the same protocol. Microcirculatory blood flow in a given time was expressed in arbitrary perfusion units (PU) and determined by software calculating the area under the curve (AUC) during the set time. Time-to-Dilation (TtD) and Time-to-Maximum Dilation (TtM) were measured from the time of KP-0013-20 application until the dilation and maximum dilation occurred. Body mass index (BMI), waist-to-hip ratio (WHR), blood pressure (BP) and heart rate (HR) were measured before functional vascular measurement.
Results: All participants were young healthy lean normotensive individuals (Table 1). As expected, men participants had higher BP and lower HR than women. In all participants, KP-0013-20 application induced significant vasodilation in upper arm skin microcirculation. Skin microvascular blood flow increased on average for 14 times. Average TtD was 11 minutes and TtM was 25 minutes. Regular ultrasound gel (placebo) did not induce any significant change in skin microvascular blood flow in all subjects.

Conclusion: External (skin surface) application of commercial product KP-0013-20 induces significant vasodilation in skin microvascular blood flow in young healthy individuals.

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2. Effects of RunningMax® gel in skin temperature values and training recovery –  Faculty of Kinesiology University of Zagreb, Cooperative for ethical finance,

The results gathered in this study suggest that application of RunningMax KP-0013-20 gel will result with lower skin temperatures. Gel was applied on one lower leg, while the other one was treated as the control sample. Three different spots were taken to collect data from, M. gastrocnemius (medial and lateral side) and M. soleus, as we found that as the most objective way to determine exact skin temperatures on affected and non-affected leg. The most significant difference in skin temperatures was found in first measuring, or five minutes after the application. In second and third measurements, a decrease in skin temperature was found. Similar conclusions were found in preliminary results, where blood flow of upper arm was monitored after the application of RunningMax KP 0013-20 gel. A significant increase was found in blood flow and vasodilatation of blood vessels of the upper arm. These findings suggest that the application of RunningMax gel can provoke recovery effects if applied properly. Best results are supposed to appear after fifteen to twenty minutes after the correct application, and that is followed with increased blod flow (vasodilatation) which indicates that That indicates recovery effects of applied gel, and justifies it’s use as a recovery method for local treatment.

Usage of such gel correctly, can significantly improve recovery time and increase the possibility of a greater number of training session while planning and programming. It is also applicable in everyday athletes or non-athletes in treating muscle soreness, or some professional impairments considering a locomotor system such as long-standing activities etc. It is important to notice that this gel works as a locally applied medium, which allows its usage on specific areas that require treatment. Its simplicity of use certainly improves everyday use and encourages consumers to choose it as a significant, and scientifically proven addition in their recovery methods repository

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